Bioactive Small Molecules
eMolecules 19171-19-8 | 4-Amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | Combi-Blocks | MFCD12756407 | 273.248 | C13H11N3O4 | 97.000 | Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 5g | 388717263
4-Amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | Combi-Blocks | 19171-19-8 | MFCD12756407 | 273.248 | C13H11N3O4 | 97.000 | Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 5g | 388717263
![Medchemexpress LLC 1-(4-dimethylphosphoryl-2-methyl-6-propan-2-ylphenyl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]py. | 2649004-88-4 | 99.9% | 635.64 g/mol | C33H36F2N5O4P | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221268.png-250.jpg)
Medchemexpress LLC 1-(4-dimethylphosphoryl-2-methyl-6-propan-2-ylphenyl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]py. | 2649004-88-4 | 99.9% | 635.64 g/mol | C33H36F2N5O4P | 5 MG
KRAS G12C inhibitor 28 is a research-grade small-molecule inhibitor selective for the KRAS G12C mutant. It shows potent in vitro activity (IC50 57 nM) and has reported antitumor effects in preclinical examples (WO2021113595A1). The compound is supplied as a high-purity solid for biochemical and cellular research applications.
- Potent KRAS G12C inhibition (IC50 57 nM).
- Demonstrated antitumor effects in preclinical examples.
- High chemical purity suitable for biochemical and cellular assays.
- Available in multiple small-mass sizes for research use.
- Molecular weight 635.64 and formula C33H36F2N5O4P for formulation planning.
Apexbio Technology LLC MG-132, 500mg. Cas: 133407-82-6 MFCD: MFCD00674886. Proteasome inhibitor, Cell permeable, reversible
MG132 (carbobenzoxy-Leu-Leu-leucinal) as a peptide aldehyde effectively blocks the proteolytic activity of proteasome complex.9 Proteasome inhibitors including MG132 have been shown to induce apoptotic cell death through formation of ROS. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC THZ1 Hydrochloride, 25mg. Cas: 1604810-83-4 (free base) MFCD: MFCD28167786. CDK7 inhibitor
THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Nilotinib(AMN-107), 1g. Cas: 641571-10-0 MFCD: MFCD09833716. Bcr-Abl kinase inhibitor,selective
Nilotinib is a selective, oral inhibitor of tyrosine kinase with IC50 values of 20, 42, 31, 38, 29 and 41 nM for the autophosphorylation of native BCR-ABL (WT p210) and mutant BCR-ABL (E281K, E292K, F317L, M351T and F486S), respectively [1]. Other sizes are available. Please inqury us for quote.
STEMCELL Technologies Z-VAD-FMK, Size: 5 mg
Z-VAD-FMK is a cell-permeable synthetic peptide that inhibits caspases and blocks caspase-mediated apoptosis in vivo (Garcia-Calvo et al.; Xiang et al.). Z-VAD-FMK prevents differentiation and enhances the freeze-thaw survival rate of human embryonic stem cells when subjected to cryopreservation conditions (Heng et al.).CANCER RESEARCH· Blocks Fas-induced apoptosis in T lymphocytes (Chow et al.).
Apexbio Technology LLC Monomethyl auristatin E, 10mg. Cas: 474645-27-7 MFCD: MFCD22124498. Antimitotic agent
IC50: less than 1 nM for various cancer cell linesMonomethyl auristatin E(MMAE) is a potent antimitotic agent by blocking the polymerisation of tubulin. Microtubules play essential role in the function of the cell. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC AEBSF.HCl, 100mg. Cas: 30827-99-7 MFCD: MFCD00132962. Serine protease inhibitor
AEBSF is a broad spectrum, irreversible inhibitor of serine proteases [1].AEBSF is a covalently binding inhibitor of proteases, including trypsin, chymotrypsin, plasmin and thrombin. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC 6 FAM SE, 10mg. Cas: 92557-81-8 MFCD: MFCD00077323. Used for labeling DNA, protein and peptide.
6-FAM SE, also known as 6-Carboxyfluorescein N-hydroxysuccinimide ester or 6-Carboxyfluorescein N-succinimidyl ester, is an isomer of carboxyfluorescein and amine-reactive succinimidyl ester carboxyfluorescein. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Cy7.5 carboxylic acid (non-sulfonated), 25mg
Cy7.5 carboxylic acid is a free un-activated NIR dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC AM251, 5mg. Cas: 183232-66-8 MFCD: MFCD01861181. Potent CB1 antagonist
AM521 is a potent cannabinoid 1 (CB1) receptor antagonist with IC50 of 8 nM and Ki of 7.49 nM.The cannabinoid receptor (CB1 and CB2) is a member of G-protein coupled receptor which plays a significant role in physiologic processes such as cognitive and immune functions. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC LMK 235, 10mg. Cas: 1418033-25-6 MFCD: MFCD26522892. HDAC4/HDAC5 inhibitor
Description:IC50: cytotoxicity IC50 (490 nm for A2780; 320 nm for A2780 CisR); HDAC inhibition (650 nM for A2780; 320 nm for A2780 CisR)Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3). Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Calcitriol, 25mg. Cas: 32222-06-3 MFCD: MFCD00867079. Active metabolite of vitamin D3
Calcitriol is a form of Vitamin D, is converted to metabolites more potent and rapidly acting than other forms of Vitamin D [1].Calcitriol has played an important role in mineral and skeletal homeostasis by regulating the differentiation, growth and the function of the cell immune system. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC MLN4924, 10mg. Cas: 905579-51-3 MFCD: MFCD17215201. NAE inhibitor
MLN4924 is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) with IC50 value of 4nM [1].MLN4924 binds NAE within the nucleotide-binding site competing with AMP. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC Alkynyl myristic acid | 82909-47-5 | MFCD18382104 | 95.0% | 224.34 g/mol | C14H24O2 | 5 MG
Alkynyl myristic acid is an alkyl chain-based reagent containing a terminal alkyne functional group, used as a click-chemistry handle and as a hydrophobic linker in chemical biology and PROTAC synthesis. It enables conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and related chemistries.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Functions as a hydrophobic linker suitable for PROTAC construction.
- Provided at high purity (95.0%) for reliable conjugation.
- Soluble in DMSO for convenient handling during synthesis.
- Available in small research-scale pack sizes for assay development.